From protein folding to cognition: a serendipitous path of discovery
Air date: Wednesday, April 19, 2017, 3:00:00 PM
Category: WALS – Wednesday Afternoon Lectures
Description: NIH Director’s Wednesday Afternoon Lecture Series
A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.
Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.
Author: Peter Walter, Ph.D., Distinguished Professor of Biochemistry and Biophysics at University of California, San Francisco; Investigator, Howard Hughes Medical Institute
Permanent link: https://videocast.nih.gov/launch.asp?23234