From protein folding to cognition: a serendipitous path of discovery 2

From protein folding to cognition: a serendipitous path of discovery



From protein folding to cognition: a serendipitous path of discovery

Air date: Wednesday, April 19, 2017, 3:00:00 PM

Category: WALS – Wednesday Afternoon Lectures

Runtime: 01:02:22

Description: NIH Director’s Wednesday Afternoon Lecture Series

A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.

Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.

Author: Peter Walter, Ph.D., Distinguished Professor of Biochemistry and Biophysics at University of California, San Francisco; Investigator, Howard Hughes Medical Institute

Permanent link: https://videocast.nih.gov/launch.asp?23234

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