Description

Cardiogen 20mg – Tetrapeptide Cardiac Bioregulator for Research

Cardiogen is a synthetic tetrapeptide composed of alanine, glutamic acid, aspartic acid, and arginine (sequence: Ala-Glu-Asp-Arg / AEDR). This short-chain peptide bioregulator has emerged as a molecular tool in cardiovascular research, with documented effects on fibroblast activity, cardiomyocyte survival signaling, and extracellular matrix dynamics.

Key Research Applications

• Cardiomyocyte and Fibroblast Biology – Research suggests that Cardiogen may regulate fibroblast proliferation and modulate cardiomyocyte apoptotic signaling. Investigations indicate it may stimulate fibroblast-driven synthesis of extracellular matrix components, including collagen and elastin, supporting structural integrity in myocardial repair contexts.

• Apoptosis and p53 Modulation – Studies demonstrate that Cardiogen (10⁻¹² M) stimulates cell proliferation in both young and old rat myocardium tissue cultures. Immunohistochemical analysis revealed a decrease in p53 protein expression, suggesting inhibition of apoptosis in myocardial tissue.

• Oxidative Stress and Cellular Research – Cardiogen may interact with cellular antioxidant pathways, potentially attenuating reactive oxygen species accumulation within cardiomyocytes. This supports cellular capacity to withstand stressors such as ischemia or metabolic challenges in model systems.

• Gene Expression and Epigenetic Studies – Investigations suggest Cardiogen may modulate transcriptional activity of genes associated with cellular survival, repair, and matrix remodeling. Studies indicate potential effects on epigenetic markers such as histone acetylation or methylation in cardiomyocyte models.

• Cross-Tissue Exploration – Cardiogen has been suggested to support non-cardiac fibroblast types, including prostate tissue research models, implying potential versatility for mammalian fibrosis research beyond cardiac contexts.

Technical Specifications

• Molecular Formula: C₁₈H₃₁N₇O₉

• Molecular Weight: ~489.47 g/mol

• Purity: ≥98% (HPLC)

• Form: Lyophilized powder

• Dosage: 20mg per vial

• Sequence: H-Ala-Glu-Asp-Arg-OH

• Synonyms: AEDR peptide, cardiac bioregulator peptide

• Storage: -20°C; avoid freeze-thaw cycles

Reconstitution Guidelines

Reconstitute the lyophilized peptide with sterile water or bacteriostatic water. Gently swirl (do not vortex) to aid dissolution. Once reconstituted, aliquot into smaller volumes and store at recommended temperatures to minimize freeze-thaw cycles.

Research Background

A PubMed-indexed study on Cardiogen’s effect on myocard tissue culture from young and old rats demonstrated significant stimulation of cell proliferation in both young and old tissues. The study also showed decreased p53 protein expression, indicating that Cardiogen inhibits apoptosis in myocardial tissue.

Important Safety Notice

⚠️ FOR RESEARCH PURPOSES ONLY

This product is strictly intended for in-vitro research and laboratory use only. It is not approved for human consumption, therapeutic use, or clinical applications by any regulatory authority. Cardiogen is not a medicinal product and has not been registered with the MHRA, EMA, or FDA.

Contraindications for Research: Individual intolerance to components; pregnancy; lactation.

This product is sold as a research chemical only. Not for human or veterinary therapeutic use.

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