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Etizolam is a short-acting psychoactive compound which goes by the trade names Etilaam and Etizest, which is not considered as a controlled substance in most parts of the world, and is legal in the US for research purposes but is not authorized by the FDA for medical use. While etizolam is also legal in many EU countries, it has been controlled in Germany, Denmark, and Switzerland. The drug is illegal in Japan and the United Kingdom. Etizolam is an analogue drug for benzodiazepines, possesses hypnotic and sedative properties, and is used in the short-term treatment of insomnia, anxiety, and depression.
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Bioactivity of Etizolam
It has hypnotic, sedative, anxiolytic, anticonvulsant, skeletal muscle relaxant and amnesic properties.
Etizolam potent hypnotic activity can be related to other short-acting benzodiazepines. The etizolam has been reported to act as a full agonist at a benzodiazepine receptor site where it exhibits a range of therapeutic and adverse effects. The pharmacological activity is produced by virtue of the thienodiazepines bonding to a benzodiazepine receptor site, where it is reported to significantly enhance the efficiency and effects of the neurotransmitter gamma-aminobutyric acid (GABA) by acting on their receptors. This receptor is the most abundantly occurring inhibitory receptor set present inside the brain; therefore its modulation consequently produces sedating/ calming effect of etizolam on the nervous system.
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Expected Physical effects of Etizolam
It can cause muscle relaxation, physical euphoria, loss of motor control, respiratory depression, increased libido, stimulation of appetite, suppression of seizure and temporary erectile dysfunction. It causes dizziness and is a dangerous rapidly acting sedative substance that can lead to complete unconsciousness on repeated doses. It produces cognitive euphoria, disinhibition, memory suppression i.e. amnesia, delusions of sobriety due to cognitive impairment, ego inflation, emotionality and motivation suppression. Under the effect of the drug, thought deceleration, suppression of analysis and temporary impairment in information processing ability is seen. All of these effects contribute towards compulsive redosing, which may cause overdosing of the drug as the user forgets, which consequently presents with an amnesic blackout state.
Increased anxiety, aggression, irritability, violence and suicidal behaviour may rarely develop and are most likely occur among recreational abusers or patients getting high-dose regimes. The after effects include rebound anxiety, dream potentiation or suppression, residual sleepiness, irritability and altered thought processing.
Dosage Information for Etizolam
The minimum dose required to produce a depressant effect is 0.2 – 0.5 mg. For mild effects, a dose of 0.5 – 1 mg is sufficient, but most commonly 1 – 2 mg is given and are available as in pill or pellet form, powder or dispensed on a blotter paper sheet. Strong depressant effects are seen when given in dosage of 2 – 5 mg and overdose has been observed in individuals taking more than 5 mg quantity of a drug or when taken with other depressants.
The total duration of action is 5 – 7 hours, with onset seen within 15 – 25 minutes and peak effects are shown after 2 – 3 hours. However, their after-effects remain for about 6 – 24 hours after the last dose taken.
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4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, designer drug, Benzos, Ettize, liquid bliss or liquid xanax, sold as “CD cleaner”.
Brand names: Etilaam, Etizest, Sedekopan, Pasaden, Depas etc.
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