SGT-78 (also known as CUMYL-CYBINACA or CUMYL-4CN-BINACA) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. While the in vitro activity of this compound is not disclosed in the associated patent, anecdotal reports suggest it is a potent cannabinoid agonist with an active dose of around 0.1mg.
SGT-78 and all other synthetic cannabinoids sold on this website are intended for research and forensic applications. The research chemical called SGT-78 is a designer drug with pronounced physiological and psychoactive effects and has the molecular formula C22H24N4O. The formula weight has the value 360.5 g/mol.
The toxicological and physiological properties of SGT-78 are not known. Synthetic cannabinoids like SGT-78 might display high affinity for peripheral CB1 and CB2 cannabinoid receptors.
1-(4-cyanobutyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide and all other designer drugs sold on this website are intended for research and forensic applications.
One study conducted on SGT-78 characterized the metabolism as well as the clearance of the research chemical using rat and human liver microsomes along with hepatocytes, which were used to compare to urine sampling and in vivo rat plasma. The study also examined hypothermia. The incubation with the microsomes showed fast metabolic clearance however, in the metabolism in vivo took longer which allowed detection in the rat plasma. The research chemical did show hypothermic effects with 28 metabolites able to be identified.
Other research shows that SGT-78 is an agonist at the receptors known as a cannabinoid. Being an analogue of a similar compound the difference noted was that an N-cumyl group replaced the N-adamantyl group. For laboratories that wish to conduct studies on SGT-78, it is important to purchase from a research chemical manufacturer that includes all data regarding how to safely handle the chemical as well as how to protect the shelf life of the chemical.
More research needs to be conducted in laboratories until data can be compiled to learn compound properties. Currently, a compound only intended for scientific and forensic research and is NOT for human consumption.
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