Synthetic cannabinoids are ingested in a similar manner to marijuana, either smoked alone in a joint or other device, such as a pipe or a bong, or rolled into a joint with tobacco or natural marijuana. This product may also be baked into foods, such as brownies, or made into tea.

Synthetic cannabinoid users report experiences similar to those produced by natural marijuana -- elevated mood, relaxation, and altered perception. Often, the effects can be stronger than those of natural marijuana due to the synthesized chemicals. Some users report psychotic effects like extreme anxiety, paranoia, and hallucinations.¹ Emergency department visits due to the effects of synthetic cannabinoid ingestion have been reported.