No, at this time there is no known xylazine antidote for safe and effective use in humans. Xylazine is NOT currently known to be reversed by naloxone (Narcan, Kloxxado, Zimhi, generics), an opiate antidote. Healthcare providers should provide appropriate supportive care to patients who do not respond adequately to naloxone administration. 

The serious side effects that can occur with xylazine use may not be reversed by narcotic antidote naloxone because xylazine is not an opioid. The reversal agents for xylazine that are used in animals (such as yohimbine or tolazoline) are not known to be safe or effective for a xylazine overdose in humans. Reversal agents regularly used in veterinary medicine should not be used in humans because it is not known if they are safe or effective in this population.

Routine toxicology screens do not identify xylazine and it may be difficult to determine if it is involved in an overdose without additional, more advanced analytical measures like gas chromatography–mass spectrometry (GC-MS). In addition, xylazine is rapidly removed from the body (half-life of 23 to 50 minutes), which may make detection even more difficult. 

Healthcare providers should continue to administer naloxone when they suspect an opioid overdose and consider that xylazine may be involved as a component of an overdose if the patient does not respond as expected.