Laws have banned kratom use in several U.S. states or counties; however, kratom is not currently regulated at the Federal level. Some states have fully classified kratom as a schedule I substance or as a banned substance, including:

• Alabama
• Arkansas
• Indiana
• Rhode Island
• Vermont
• Wisconsin

The American Kratom Association is a lobbying and advocacy group in support of kratom use. The American Kratom Association reports that there are a number of misconceptions, misunderstandings and lies floating around about Kratom. They advocate to "fight anti-kratom legislation across the United States."

The FDA continues to seize adulterated dietary supplements containing kratom. Seized brand names have included: Boosted Kratom, The Devil’s Kratom, Terra Kratom, Sembuh, Bio Botanical, and El Diablo. There are no currently no FDA approved uses for kratom.