Nootropics, also known as “smart drugs” or cognitive enhancers, have gained immense popularity for their ability to improve mental performance, focus, and creativity. Among their many benefits, some nootropics are praised for their ability to induce euphoria—a profound sense of happiness, well-being, and mental clarity. In 2025, advancements in neuroscience and pharmacology have brought a new generation of nootropics that stand out for their euphoric effects.
Below, we explore the top 10 best nootropics for euphoria in 2025, including their benefits, mechanisms of action, and safety considerations.
1. Phenylpiracetam
- Why it’s euphoric: Phenylpiracetam is a powerful racetam derivative known for boosting dopamine levels, which enhances mood and motivation.
- Benefits: Increased energy, focus, and emotional resilience.
- Dosage: 100–200 mg per day.
- Caution: Use sparingly to avoid tolerance.
2. Tianeptine
- Why it’s euphoric: Tianeptine acts as an atypical antidepressant by modulating glutamate and serotonin systems, offering mood-enhancing effects.
- Benefits: Stress reduction, anxiety relief, and enhanced well-being.
- Dosage: 12.5 mg, up to three times daily.
- Caution: Risk of dependency with overuse.
3. Bromantane
- Why it’s euphoric: This unique adaptogen and stimulant increases dopamine activity while reducing fatigue.
- Benefits: Mental energy, improved focus, and a calming sense of euphoria.
- Dosage: 50–100 mg per day.
- Caution: Avoid taking it late in the day as it may disrupt sleep.
4. Modafinil
- Why it’s euphoric: Modafinil is a wakefulness-promoting agent that enhances dopamine and serotonin levels, contributing to a mood uplift.
- Benefits: Heightened alertness, improved productivity, and mood stabilization.
- Dosage: 100–200 mg in the morning.
- Caution: Prescription may be required in some regions.
5. 9-MBC (9-Methyl-β-Carboline)
- Why it’s euphoric: A potent dopamine enhancer, 9-MBC supports long-term motivation and mood improvement.
- Benefits: Enhanced energy, positivity, and cognitive function.
- Dosage: 5–15 mg daily.
- Caution: Long-term safety studies are still ongoing.
6. Phenibut
- Why it’s euphoric: Phenibut interacts with GABA receptors to promote relaxation and a sense of well-being.
- Benefits: Anxiety relief, improved social interactions, and mood enhancement.
- Dosage: 250–750 mg as needed (not daily).
- Caution: Use with caution to avoid dependence and tolerance.
7. Noopept
- Why it’s euphoric: Noopept stimulates brain-derived neurotrophic factor (BDNF), improving mood, memory, and mental clarity.
- Benefits: Cognitive enhancement, mood stabilization, and stress reduction.
- Dosage: 10–30 mg per day.
- Caution: Take breaks to prevent tolerance.
8. Kratom (Mitragyna Speciosa)
- Why it’s euphoric: Certain strains of kratom, particularly white and green veins, offer mild euphoria by activating opioid and dopamine receptors.
- Benefits: Pain relief, enhanced focus, and mood uplift.
- Dosage: 2–5 grams for mild effects.
- Caution: Use responsibly to avoid dependency.
9. Alpha-GPC
- Why it’s euphoric: A choline source, Alpha-GPC supports acetylcholine production, improving brain function and inducing a sense of calm focus.
- Benefits: Better memory, enhanced concentration, and a slight mood lift.
- Dosage: 300–600 mg per day.
- Caution: Monitor for headaches if combined with other choline-based nootropics.
10. Rhodiola Rosea
- Why it’s euphoric: This adaptogen reduces stress and fatigue while enhancing dopamine sensitivity, improving mood and motivation.
- Benefits: Reduced anxiety, enhanced mental clarity, and improved physical endurance.
- Dosage: 200–400 mg per day.
- Caution: Ensure your supplement contains a standardized extract.
How to Use Nootropics Safely for Euphoria
- Start Low, Go Slow: Begin with the lowest effective dose to understand your body’s response.
- Cycle Usage: Avoid continuous use of nootropics that may cause tolerance or dependency, such as Phenibut and Tianeptine.
- Consult a Professional: If you have any underlying health conditions or are taking medications, consult a healthcare provider before using nootropics.
- Prioritize Quality: Purchase from reputable vendors to ensure purity and efficacy.
Final Thoughts
Nootropics for euphoria can offer transformative effects, helping users experience greater happiness, motivation, and mental clarity. However, they should be used responsibly, with a focus on balance and long-term well-being. Whether you’re seeking a mood boost, enhanced productivity, or simply a better outlook on life, the nootropics listed here can be valuable tools in 2025’s evolving wellness landscape.